Your browser version may not work well with NCBI's Web applications. More information here...
1: Theor Biol Med Model. 2007 Sep 7;4:34.Click here to read Click here to read Links

The allosteric modulation of lipases and its possible biological relevance.

Köhler J, Wünsch B.

Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Hittorfstrasse 58-62, D-48149 Münster, Germany. jenskoeh@uni-muenster.de

BACKGROUND: During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown. THEORY: Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism. CONCLUSION: This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.

PMID: 17825093 [PubMed - indexed for MEDLINE]

PMCID: PMC2020465