Utilizing combination therapy for ethnic skin

Cutis. 2007 Jul;80(1 Suppl):15-20.

Abstract

A major issue in treating acne in individuals of color is the need to treat and prevent postinflammatory hyperpigmentation (PIH), which is common in this population. This subset analysis reports the pigmentary changes in subjects of color with acne who were enrolled in a community-based trial comparing 3 different topical therapeutic regimens. All subjects received combination clindamycin 1%-benzoyl peroxide (BPO) 5% topical gel containing glycerin and dimethicone. Subjects were randomized to receive this combination therapy in addition to either a tretinoin microsphere (RAM) gel at concentrations of either 0.04% or 0.1% or adapalene (AP) gel 0.1%. There was a trend toward better resolution of hyperpigmentation in the subjects receiving the clindamycin-BPO topical gel in combination with RAM gel 0.04%.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / ethnology*
  • Adapalene
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Asian People
  • Benzoyl Peroxide / pharmacology
  • Benzoyl Peroxide / therapeutic use
  • Black or African American
  • Clindamycin / pharmacology
  • Clindamycin / therapeutic use
  • Dermatologic Agents / pharmacology
  • Dermatologic Agents / therapeutic use
  • Dimethylpolysiloxanes / pharmacology
  • Drug Combinations
  • Drug Therapy, Combination
  • Glycerol / pharmacology
  • Hispanic or Latino
  • Humans
  • Hyperpigmentation / drug therapy*
  • Hyperpigmentation / ethnology
  • Hyperpigmentation / etiology
  • Hyperpigmentation / prevention & control*
  • Keratolytic Agents / pharmacology
  • Keratolytic Agents / therapeutic use
  • Naphthalenes / pharmacology
  • Naphthalenes / therapeutic use
  • Randomized Controlled Trials as Topic
  • Skin Pigmentation / drug effects*
  • Tretinoin / pharmacology
  • Tretinoin / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Dermatologic Agents
  • Dimethylpolysiloxanes
  • Drug Combinations
  • Keratolytic Agents
  • Naphthalenes
  • Adapalene
  • Clindamycin
  • Tretinoin
  • dimethicone
  • Glycerol
  • Benzoyl Peroxide