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Int J Oral Maxillofac Surg. 2007 Dec;36(12):1183-92. Epub 2007 Sep 6.

Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction.

Author information

  • 1Oral & Maxillofacial Surgery, Glasgow Dental Hospital & School, Glasgow, UK. a.ayoub@dental.gla.ac.uk <a.ayoub@dental.gla.ac.uk>

Abstract

The aim of this study was to investigate the feasibility of reconstructing critical size continuity osteoperiosteal defects of the mandible using a composite of recombinant BMP-7 contained in a bovine type-1 collagen carrier wrapped in a pedicled sterno-occipitalis muscle flap. At 3 months following surgery, bridging of the surgical defect was noted in three subjects (60%). Histologically, the induced bone regenerate showed maturation from woven to lamellar bone. Islands of cartilage were distributed throughout the defect. Replacement ossification of the degenerated muscle was a common feature in all specimens. Microradiography showed a gradual increase in the calcification of mineralized tissue from the margin to the centre of the newly generated bone. This research represents a proof of the concept that bone can be satisfactorily formed within a muscular scaffolding at the site of the created defect in a one-stage procedure.

PMID:
17822878
[PubMed - indexed for MEDLINE]
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