Acta Neurol Belg. 1991;91(5):288-95.

Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.

Salmon E, Maquet P, Sadzot B, Degueldre C, Lemaire C, Franck G.

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Department of Neurology, University of Liège, Belgium.

Abstract

Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young volunteers. Cortical atrophy or neuronal depopulation are unlikely to entirely explain this physiological phenomenon, and sub-cortico-cortical deactivation should play a role, analogous to that proposed in subcortical diseases.

PMID:: 1781265; [PubMed - indexed for MEDLINE]

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