Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Environ Health Perspect. 2007 Sep;115(9):1293-7.

Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats.

Author information

  • 1Cesare Maltoni Cancer Research Center, European Ramazzini Foundation of Oncology and Environmental Sciences, Bologna, Italy. crcfr@ramazzini.it

Abstract

BACKGROUND:

In a previous study conducted at the Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation (CMCRC/ERF), we demonstrated for the first time that aspartame (APM) is a multipotent carcinogenic agent when various doses are administered with feed to Sprague-Dawley rats from 8 weeks of age throughout the life span.

OBJECTIVE:

The aim of this second study is to better quantify the carcinogenic risk of APM, beginning treatment during fetal life.

METHODS:

We studied groups of 70-95 male and female Sprague-Dawley rats administered APM (2,000, 400, or 0 ppm) with feed from the 12th day of fetal life until natural death.

RESULTS:

Our results show a) a significant dose-related increase of malignant tumor-bearing animals in males (p < 0.01), particularly in the group treated with 2,000 ppm APM (p < 0.01); b) a significant increase in incidence of lymphomas/leukemias in males treated with 2,000 ppm (p < 0.05) and a significant dose-related increase in incidence of lymphomas/leukemias in females (p < 0.01), particularly in the 2,000-ppm group (p < 0.01); and c) a significant dose-related increase in incidence of mammary cancer in females (p < 0.05), particularly in the 2,000-ppm group (p < 0.05).

CONCLUSIONS:

The results of this carcinogenicity bioassay confirm and reinforce the first experimental demonstration of APM's multipotential carcinogenicity at a dose level close to the acceptable daily intake for humans. Furthermore, the study demonstrates that when life-span exposure to APM begins during fetal life, its carcinogenic effects are increased.

KEYWORDS:

Sprague-Dawley; artificial sweeteners; aspartame; carcinogenicity; lymphomas/leukemias; mammary cancers; prenatal exposure

Comment in

PMID:
17805418
[PubMed - indexed for MEDLINE]
PMCID:
PMC1964906
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for National Institute of Environmental Health Sciences Icon for PubMed Central
    Loading ...
    Write to the Help Desk