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Bioinformatics. 2007 Dec 1;23(23):3263-4. Epub 2007 Sep 5.

Phylocomposer and phylodirector: analysis and visualization of transducer indel models.

Author information

  • Department of Bioengineering, University of California, Berkeley, CA, USA. ihh@berkeley.edu

Abstract

Finite-state string transducers are probabilistic tools similar to Hidden Markov Models that can be systematically extended to large number of sequences related by indel and substitution processes on phylogenetic trees. The number of states in such models grows exponentially with the number of nodes in the tree, with the consequence that even quite small trees can be difficult to analyze or visualize. Here, we present two tools, phylocomposer and phylodirector, for working with string transducers. The former tool implements previously described composition algorithms for extending transducers to arbitrary tree topologies, while the latter generates short animations for arbitrary input alignments and phylogenetic trees, illustrating the state path through the composed transducer.

AVAILABILITY:

Phylocomposer and phylodirector are freely available at http://biowiki.org/PhyloComposer and http://biowiki.org/PhyloDirector

PMID:
17804439
[PubMed - indexed for MEDLINE]
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