Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biomol Eng. 2007 Nov;24(5):472-6. Epub 2007 Aug 2.

Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin.

Author information

  • 1Laboratoire de Chimie Organique et MacromolĂ©culaire, UniversitĂ© des Sciences et Technologies de Lille, UMR CNRS 8009, 59655 Villeneuve d'Ascq Cedex, France.

Abstract

Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate (DigCHX) instead of 1mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and beta-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.

PMID:
17804290
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk