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1: Genome Biol. 2007;8(9):R185.Click here to read Click here to read Links

Cross-species cluster co-conservation: a new method for generating protein interaction networks.

Karimpour-Fard A, Detweiler CS, Erickson KD, Hunter L, Gill RT.

Center for Computational Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation.

PMID: 17803817 [PubMed - indexed for MEDLINE]

PMCID: PMC2375023