Pharmacol Biochem Behav. 1991 Sep;40(1):79-82.

Effect of naltrexone upon self-injurious behavior, learning and activity: a case study.

Taylor DV, Hetrick WP, Neri CL, Touchette P, Barron JL, Sandman CA.

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Department of Psychiatry and Human Behavior, University of California, Irvine.

Abstract

Naltrexone significantly attenuated self-injurious behavior in a 20-year-old mildly retarded autistic male patient. The patient was videotaped daily and behavior was evaluated with a time-sampling procedure. Behavioral ratings of SIB frequency, SIB severity, and activity were collected automatically with a computerized system. Learning and memory were tested on a weekly basis with a modification of a paired associate learning test (PALT). Treatment with naltrexone resulted in (a) attenuation of SIB in the unstructured setting and (b) improvements in learning and memory without influencing activity levels.

PMID:: 1780350; [PubMed - indexed for MEDLINE]

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