Science. 1968 Feb 16;159(3816):741-3.

Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity.

Stamatoyannopoulos G, Yoshida A, Adamson J, Heinenberg S.

Abstract

Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. Structurally, it represents substitution of histidine for the invariant residute H23 tyrosine in the beta-hemoglobin polypeptide chain (beta(145) tyrosine --> histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation.

PMID:: 17795074; [PubMed]

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Single chain alkali resistance in hemoglobin Rainier: beta 145 tyrosine-histidine. [Science. 1969]
Single chain alkali resistance in hemoglobin Rainier: beta 145 tyrosine-histidine.
Stamatoyannopoulos G, Yoshida A. Science. 1969 Nov 21; 166(3908):1005-6.
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Hb Rainier [beta145(HC2)Tyr-->Cys] in Italy. Characterization of the amino acid substitution and the DNA mutation.
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Kleckner HB, Wilson JB, Lindeman JG, Stevens PD, Niazi G, Hunter E, Chen CJ, Huisman TH. Biochim Biophys Acta. 1975 Aug 19; 400(2):343-7.

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Cited by 4 PubMed Central articles

Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation. [J Clin Invest. 1969]
Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation.
Adamson JW, Parer JT, Stamatoyannopoulos G. J Clin Invest. 1969 Aug; 48(8):1376-86.
Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia. [J Clin Invest. 1969]
Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia.
Hamilton HB, Iuchi I, Miyaji T, Shibata S. J Clin Invest. 1969 Mar; 48(3):525-35.
Subunit dissociation of certain abnormal human hemoglobins. [J Clin Invest. 1969]
Subunit dissociation of certain abnormal human hemoglobins.
Bunn HF. J Clin Invest. 1969 Jan; 48(1):126-38.

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Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity.

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