Int J Clin Pract. 2007 Nov;61(11):1922-30. Epub 2007 Sep 3.

Emerging oral therapies for multiple sclerosis.

Source

Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. bac106@northwestern.edu

Abstract

BACKGROUND: Current disease-modifying drugs (DMDs) have positively affected the treatment of relapsing-remitting multiple sclerosis (RRMS); however, the requirement for long-term injections imposes a burden on patients and may lead to reduced adherence in some cases. Furthermore, not all patients respond adequately to current DMDs, suggesting that certain patients require different therapeutic approaches. Therefore, alternative MS treatments with less invasive routes of administration and new modes of action are needed to expand the current treatment repertoire, increase patient satisfaction and adherence, and thereby improve efficacy. DISCUSSION: This review discusses the current unmet need for an orally administered treatment for RRMS, including potential benefits of this route of administration, and implications for improved treatment outcomes. Oral drugs that are currently in Phase II/III clinical development are discussed.

PMID:: 17784852; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Emerging oral drugs for relapsing-remitting multiple sclerosis. [Expert Opin Emerg Drugs. 2011]
Review Emerging oral drugs for relapsing-remitting multiple sclerosis.
Gasperini C, Ruggieri S. Expert Opin Emerg Drugs. 2011 Dec; 16(4):697-712. Epub 2011 Dec 7.
Review Cladribine tablets' potential in multiple: sclerosis treatment. [J Neurosci Nurs. 2008]
Review Cladribine tablets' potential in multiple: sclerosis treatment.
Costello K, Sipe JC. J Neurosci Nurs. 2008 Oct; 40(5):275-80.
Review Emerging oral drugs for multiple sclerosis. [Expert Opin Emerg Drugs. 2008]
Review Emerging oral drugs for multiple sclerosis.
Gasperini C, Cefaro LA, Borriello G, Tosto G, Prosperini L, Pozzilli C. Expert Opin Emerg Drugs. 2008 Sep; 13(3):465-77.
Review Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis. [Expert Rev Neurother. 2010]
Review Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis.
Sipe JC. Expert Rev Neurother. 2010 Mar; 10(3):365-75.
Comparing the cost-effectiveness of disease-modifying drugs for the first-line treatment of relapsing-remitting multiple sclerosis. [J Manag Care Pharm. 2009]
Comparing the cost-effectiveness of disease-modifying drugs for the first-line treatment of relapsing-remitting multiple sclerosis.
Goldberg LD, Edwards NC, Fincher C, Doan QV, Al-Sabbagh A, Meletiche DM. J Manag Care Pharm. 2009 Sep; 15(7):543-55.

See reviews... See all...

Cited by 6 PubMed Central articles

Escalating immunotherapy of multiple sclerosis. [Ther Adv Neurol Disord. 2008]
Escalating immunotherapy of multiple sclerosis.
Rieckmann P, Traboulsee A, Devonshire V, Oger J. Ther Adv Neurol Disord. 2008 Nov; 1(3):181-92.
Potential short-term use of oral cladribine in treatment of relapsing-remitting multiple sclerosis. [Neuropsychiatr Dis Treat. 2010]
Potential short-term use of oral cladribine in treatment of relapsing-remitting multiple sclerosis.
Murphy JA, Harris JA, Crannage AJ. Neuropsychiatr Dis Treat. 2010 Oct 5; 6:619-25. Epub 2010 Oct 5.
New oral disease-modifying therapies for multiple sclerosis. [F1000 Med Rep. 2009]
New oral disease-modifying therapies for multiple sclerosis.
Bagert BA, Bourdette D. F1000 Med Rep. 2009 May 8; 1. Epub 2009 May 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Emerging oral therapies for multiple sclerosis.
Emerging oral therapies for multiple sclerosis.
Int J Clin Pract. 2007 Nov ;61(11):1922-30. Epub 2007 Sep 3 .

PubMed
DNA oligonucleotide-cis-platin binding: Ab initio interpretation of the vibratio...
DNA oligonucleotide-cis-platin binding: Ab initio interpretation of the vibrational spectra.
J Phys Chem A. 2007 Oct 4 ;111(39):9714-23. Epub 2007 Sep 5 .

PubMed
[An attempt to locate the gene for congenital cataracts using linkage analysis].
[An attempt to locate the gene for congenital cataracts using linkage analysis].
Genetika. 1991 Oct ;27(10):1840-9.

PubMed
[Red cell system and selected red cell enzymes in men occupationally exposed to ...
[Red cell system and selected red cell enzymes in men occupationally exposed to mercury vapours].
Przegl Lek. 2006 ;63 Suppl 7:74-83.

PubMed
Fluid processes in subduction zones.
Fluid processes in subduction zones.
Science. 1990 Apr 20 ;248(4953):329-37.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: