Frontiers of science are usually considered as those areas where the boundares of human knowledge are being pushed most vigorousl into the unknown. These are the intemal frontiers. But no less important are the external frontiers. Those bordering on the federal govermment, on education, on private industry and on intemational affairs and the developing world are among the most critical and demanding. Some of the outstanding problems facing science, and scientists in these extemal interactions, are discussed within the context of our changing national and international priorities.