Monitoring of concordance in growth hormone therapy

R R Kapoor; S A Burke; S E Sparrow; I A Hughes; D B Dunger; K K Ong; C L Acerini

doi:10.1136/adc.2006.114249

Monitoring of concordance in growth hormone therapy

Arch Dis Child. 2008 Feb;93(2):147-8. doi: 10.1136/adc.2006.114249. Epub 2007 Sep 3.

Authors

R R Kapoor¹, S A Burke, S E Sparrow, I A Hughes, D B Dunger, K K Ong, C L Acerini

Affiliation

¹ Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

PMID: 17768149
DOI: 10.1136/adc.2006.114249

Abstract

Concordance with growth hormone (GH) therapy in 75 children was objectively assessed using data on GP prescriptions over 12 months. 23% missed >2 injections/week. Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05).

MeSH terms

Adolescent
Body Height / drug effects
Child
Cross-Sectional Studies
Drug Administration Schedule
Drug Monitoring / methods
Drug Prescriptions / statistics & numerical data
Female
Growth Disorders / drug therapy*
Growth Disorders / physiopathology
Human Growth Hormone / administration & dosage*
Human Growth Hormone / therapeutic use
Humans
Longitudinal Studies
Male
Patient Compliance*
Recombinant Proteins / administration & dosage
Recombinant Proteins / therapeutic use
Treatment Outcome

Substances

Recombinant Proteins
Human Growth Hormone