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Nat Genet. 2007 Oct;39(10):1200-1. Epub 2007 Sep 2.

Variation in complement factor 3 is associated with risk of age-related macular degeneration.

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  • 1Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.

PMID:
17767156
[PubMed - indexed for MEDLINE]
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