Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Hered. 2007 Sep-Oct;98(6):555-66. Epub 2007 Sep 1.

Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats.

Author information

  • 1The Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, MD 21702, USA. jkehler@ncifcrf.gov

Abstract

To determine the genetic regulation of "hair length" in the domestic cat, a whole-genome scan was performed in a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds > or = 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candidate gene implicated in regulating hair follicle growth cycle in other species. Sequence analyses of FGF5 in 26 cat breeds and 2 pedigrees of nonbreed cats revealed 4 separate mutations predicted to disrupt the biological activity of the FGF5 protein. Pedigree analyses demonstrated that different combinations of paired mutant FGF5 alleles segregated with the long-haired phenotype in an autosomal recessive manner. Association analyses of more than 380 genotyped breed and nonbreed cats were consistent with mutations in the FGF5 gene causing the long-haired phenotype in an autosomal recessive manner. In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat.

PMID:
17767004
[PubMed - indexed for MEDLINE]
PMCID:
PMC3756544
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure A1
Figure A2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk