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Mol Biochem Parasitol. 2007 Dec;156(2):93-101. Epub 2007 Jul 19.

Post-transcriptional regulation of gene expression in trypanosomes and leishmanias.

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  • 1Zentrum für Molekualre Biologie der Universität Heidelberg, Im Neuenheimer Feld 282, D69120 Heidelberg, Germany. cclayton@zmbh.uni-heidelberg.de


Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated.

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