Am J Infect Control. 2007 Sep;35(7):486-8.

Absence of pharyngeal shedding of vaccinia following smallpox vaccination.

Talbot TR, Peters J, Wright PF, Edwards KM.

Source

Division of Infectious Diseases in the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. tom.talbot@vanderbilt.edu

Abstract

To examine oral shedding of vaccinia in volunteers who were recently vaccinated against smallpox, pharyngeal swabs were collected for viral culture between days 3 and 5 and days 6 and 8 after vaccination with diluted Sanofi Pasteur smallpox vaccine. From 102 adult volunteers (48 vaccinia-naive, 54 vaccinia-experienced), vaccinia was not detected in any specimen (0/201, 95% confidence interval, 0-1.8), which suggests a lack of oral shedding of vaccinia after immunization. This supports recommendations that individuals who were recently vaccinated against smallpox do not require placement in airborne or droplet precautions.

PMID:: 17765564; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Smallpox Vaccine

Grant Support

N01-AI-25462/AI/NIAID NIH HHS/United States

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