Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2007 Sep;15(9):417-25. Epub 2007 Aug 30.

Offering surprises: TCA cycle regulation in Corynebacterium glutamicum.

Author information

  • 1Institut für Biotechnologie 1, Forschungszentrum Jülich, D-52425 Jülich, Germany. m.bott@fz-juelich.de

Abstract

Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptional level, but also at the post-transcriptional level. The latter involves serine/threonine protein kinase G and its target protein OdhI. Depending on its phosphorylation state, OdhI inhibits the 2-oxoglutarate dehydrogenase complex. This new type of TCA cycle control will be reviewed here together with regulation at the level of gene expression.

PMID:
17764950
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk