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1: Br J Clin Pharmacol. 2007 Nov;64(5):566-74. Epub 2007 Aug 31.Click here to read Click here to read Links
Comment in:
Br J Clin Pharmacol. 2007 Nov;64(5):563-5.

Thioridazine: resurrection as an antimicrobial agent?

Thanacoody HK.

Royal Infirmary of Edinburgh, Edinburgh, UK. ruben.thanacoody@luht.scot.nhs.uk

The emergence of multiresistant bacterial strains and the continuing burden of infectious disease globally point to the urgent need for novel affordable antimicrobial drugs. Thioridazine is a phenothiazine antipsychotic drug with well-recognized antimicrobial activity, but this property has not been harnessed for clinical use as a result of its central nervous system and cardiac side-effects. The cardiotoxicity of thioridazine has recently been shown to be structurally specific at a molecular level, whereas its antimicrobial properties are shared by a number of phenothiazine analogues. This raises the possibility that its enantiomers or its inactive metabolite, the ring sulphoxide, may act as a lead compound in the future development of antimicrobial drugs to face the new challenges in infectious disease.

PMID: 17764469 [PubMed - indexed for MEDLINE]

PMCID: PMC2203271

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  • Thioridazine

    Thioridazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in people who have already been tre...

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