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Br J Clin Pharmacol. 2007 Nov;64(5):566-74. Epub 2007 Aug 31.

Thioridazine: resurrection as an antimicrobial agent?

Author information

  • Royal Infirmary of Edinburgh, Edinburgh, UK. ruben.thanacoody@luht.scot.nhs.uk

Abstract

The emergence of multiresistant bacterial strains and the continuing burden of infectious disease globally point to the urgent need for novel affordable antimicrobial drugs. Thioridazine is a phenothiazine antipsychotic drug with well-recognized antimicrobial activity, but this property has not been harnessed for clinical use as a result of its central nervous system and cardiac side-effects. The cardiotoxicity of thioridazine has recently been shown to be structurally specific at a molecular level, whereas its antimicrobial properties are shared by a number of phenothiazine analogues. This raises the possibility that its enantiomers or its inactive metabolite, the ring sulphoxide, may act as a lead compound in the future development of antimicrobial drugs to face the new challenges in infectious disease.

Comment in

  • Old drugs--new uses. [Br J Clin Pharmacol. 2007]
PMID:
17764469
[PubMed - indexed for MEDLINE]
PMCID:
PMC2203271
Free PMC Article

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