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Acta Neurol Scand. 1991 Nov;84(5):403-6.

The influence of pregnancy on relapses in multiple sclerosis: a cohort study.

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  • 1Department of Neurological Sciences, University of Rome, Italy.


The influence of pregnancy on the relapse rate (number of relapses per person per year) in MS was analysed for 52 women who had a pregnancy during the disease. The relapse rate was lower during the pregnancy-year (9 months of pregnancy and 6 months immediately post partum) than the non-pregnancy time. There was a heterogeneous pattern during the pregnancy-year with a sharp decrease in the relapse rate observed during pregnancy and a slight non-significant increase in the puerperium: both these relapse rates were compared with figures observed in the same group of women during the non-pregnancy time. Pregnancy does not appear to be a period at greater risk for exacerbations but, on the contrary it seems to act, on the whole, as a protective event. These data allow physicians to provide reassuring counselling to women.

Comment in

  • Pregnancy in multiple sclerosis. [Acta Neurol Scand. 1992]
[PubMed - indexed for MEDLINE]
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