Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Genomics Proteomics. 2007 Jan-Feb;4(1):21-5.

Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia.

Author information

  • 1University of Kansas Medical Center, Department of Microbiology, Immunology and Molecular Genetics, 3025 Wahl Hall West, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

Abstract

One in seven types of human cancer is associated with an oncogenic virus infection. Most human tumors have high telomerase activity but very short telomeres, yet the maintenance of these short telomeres is critical to avoid telomere end fusion or senescence and to support active proliferation. Oncogenic viruses have evolved a wide repertoire of strategies to stimulate telomerase functions at the transcriptional and post-transcriptional levels. Since telomerase activity is absent in somatic cells, the inhibition of telomerase is an attractive target for cancer therapeutics.

PMID:
17726237
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk