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Aging Cell. 2007 Dec;6(6):841-2. Epub 2007 Aug 24.

Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner.

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  • 1NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain.


There is growing evidence that herpes simplex virus type 1 (HSV-1), together with the apolipoprotein E 4 (APOE4) allele, contribute to the pathogenesis of Alzheimer's disease (AD), although the mechanism of their interaction remains uncertain. Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD.

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