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Crit Rev Immunol. 2007;27(2):141-51.

Novel functions of B cells.

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  • 1Transplantation Biology and the Departments of Immunology, Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.


T cells clearly help B cells to produce antibodies and acquire memory. Recently, B cells were found to support some T-cell responses through antigen presentation, and perhaps more importantly, through the generation of diverse T cells and lymphoid organogenesis. These new findings show that the development and function of T cells depend on B cells independently of specific antibody production.

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