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Immunity. 2007 Aug;27(2):183-5.

Islet beta-cell death - fuel to sustain autoimmunity?

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  • 1La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. christophe@liai.org

Abstract

Under what context do dying beta-cells enhance the autoimmune process in type 1 diabetes? Kim et al. (2007) find that secondary necrosis of beta-cells can prime the autoimmune response via uptake by and activation of antigen-presenting cells through Toll-like receptor 2.

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