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Immunity. 2007 Aug;27(2):173-8.

Revving the engine: signal transduction fuels T cell activation.

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  • 1Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.


For initiation of an immune response, resting T cells must reprogram their metabolism. Continuing the "From the Field" series (see Editorial [2007] 26, 131), Jones and Thompson draw attention to the importance of metabolism during T cell activation and consider how this process is regulated by receptor-mediated signal transduction.

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