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    Pediatr Infect Dis J. 2007 Sep;26(9):852-4.

    No decrease in clindamycin susceptibility despite increased use of clindamycin for pediatric community-associated methicillin-resistant Staphylococcus aureus skin infections.

    Szczesiul JM, Shermock KM, Murtaza UI, Siberry GK.

    Source

    Department of Pharmacy, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA. jilliansz13@aol.com

    Abstract

    A previous study at our institution revealed 98% of methicillin-resistant Staphylococcus aureus (MRSA) isolates were susceptible to clindamycin; however, beta-lactams were then the predominant empiric treatment. This follow-up chart review study examined subsequent staphylococcal skin and soft tissue infection treatment and susceptibility patterns over a 2-year period. Of 296 S. aureus skin and soft tissue infections, 73% were MRSA, of which 87% were community-associated-MRSA; MRSA infections peaked in warm summer months. Despite a significant increase in empiric clindamycin use, 97% of community-associated-MRSA isolates retained susceptibility to clindamycin.

    PMID:
    17721387
    [PubMed - indexed for MEDLINE]

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