Biochem Biophys Res Commun. 2007 Oct 26;362(3):550-3. Epub 2007 Aug 20.

Bone morphogenetic protein.

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College of Life Sciences, Zhejiang University, 310058, China.

Abstract

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis. However, their hallmark ability is that play a pivotal role in inducing bone, cartilage, ligament, and tendon formation at both heterotopic and orthotopic sites. In this review, we mainly concentrate on BMP structure, function, molecular signaling and potential medical application.

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