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Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52.

Self-eating and self-killing: crosstalk between autophagy and apoptosis.

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  • 1INSERM, U848, F-94805 Villejuif, France.

Abstract

The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.

PMID:
17717517
[PubMed - indexed for MEDLINE]
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