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Adv Drug Deliv Rev. 2007 Aug 31;59(9-10):883-95. Epub 2007 Jul 13.

Rhythmic pattern in pain and their chronotherapy.

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  • 1Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5, France. bernard.bruguerolle@medecine.univ-mrs.fr

Abstract

Pain control is one of the most important therapeutic priorities; nonetheless, inadequate pain relief remains a significant health care issue. Thus, it is important to determine whether the analgesic effect can be improved by using the chronopharmacological approach. This paper reviews the data on the rhythmic patterns in pain level and their chronotherapy. It underlines the major issues and problems related to the development of chronotherapeutic strategies, and it examines emerging aspects of new drug-delivery systems for achieving such.

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