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Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA. malbert9@jhmi.edu
Mild cognitive impairment (MCI) is a clinical syndrome thought to represent the transition between normal function and dementia. This review describes data that support the existence of such a transitional phase, outlines the heterogeneity of MCI and how that has influenced the evolving concept of MCI, and discusses the impact of heterogeneity on recent MCI clinical trials.
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