Curr Biol. 2007 Aug 21;17(16):R630-2.

Replication licensing: oops! ... I did it again.

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Division of Developmental Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Abstract

All eukaryotes use multiple controls to restrict DNA replication to once per cell cycle. Nevertheless, inactivation of a single gene, cul-4, causes massive re-replication in Caenorhabditis elegans. A novel study explains this dramatic phenotype by demonstrating that the CUL-4 E3 ligase simultaneously controls two critical licensing factors: CDT-1 and CDC-6.

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Curr Biol. 2007 Jun 5;17(11):966-72.

PMID:: 17714648; [PubMed - indexed for MEDLINE]

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CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. [Nature. 2003]
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Cited by 2 PubMed Central articles

Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. [PLoS Genet. 2011]
Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.
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C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability. [Dev Biol. 2011]
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.
Korzelius J, The I, Ruijtenberg S, Portegijs V, Xu H, Horvitz HR, van den Heuvel S. Dev Biol. 2011 Feb 15; 350(2):358-69. Epub 2010 Dec 10.

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