Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Mol Neurobiol. 2008 Jun;28(4):491-9. Epub 2007 Aug 21.

Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction.

Author information

  • 1State Key laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Rm# 2-315, Shanghai 201203, China.

Abstract

The tetrahydroprotoberberines (THPBs) are compounds isolated from Chinese herbs that possess a unique pharmacological profile as D2 dopamine receptor antagonists and D1 receptor agonists. l-Tetrahydropalmatine (l-THP) and l-stepholidine (SPD), members of the THPB family, were shown to have potential clinical use in the treatment of pain. However, their mechanism of action is not clear. In the past decades, Chinese scientists have made a great deal of effort to explore the mechanisms by which the THPBs and its analogues elicit antinociception and their potential utility in treating drug abuse. It is now clear that the antinociception produced by l-THP is related to inhibition of D(2) dopamine receptors. The present review focuses on the recent progress made in understanding the mechanisms of l-THP- and l-SPD-mediated antinociception and the sequel of drug addiction.

PMID:
17710533
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk