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    Biochem Biophys Res Commun. 2007 Oct 12;362(1):193-9. Epub 2007 Aug 10.

    TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland.

    Lee NO, Son YJ, Kim JG, Ha CM, Yun CH, Lim HL, Park JW, D'Elia AV, Damante G, Lee BJ.

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    Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea.

    Abstract

    Thyroid transcription factor 1 (TTF-1) is required for morphogenesis of the fetal diencephalon. Previous reports showed that mice carrying a TTF-1 null mutation lacked normal development of the pituitary gland. In this study, a role for TTF-1 in the regulation of growth hormone and prolactin transcription was identified. In-situ hybridization analysis demonstrated TTF-1 mRNA in the growth hormone-producing cells and prolactin-producing cells of the rat anterior pituitary gland. In the GH3 pituitary cell line, we identified TTF-1 as a factor functionally regulating growth hormone and prolactin transcription. TTF-1 activated prolactin transcription, but inhibited growth hormone transcription. Inhibition and activation of growth hormone and prolactin transcription, respectively, by TTF-1 disappeared upon deletion of the TTF-1 binding motifs within the promoters of these genes. These data suggest that TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones.

    PMID:
    17706597
    [PubMed - indexed for MEDLINE]

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