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FEBS Lett. 2007 Sep 4;581(22):4235-40. Epub 2007 Aug 7.

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

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  • 1Unit of Endocrinology and Metabolism UCL 55.30, Faculty of Medicine, Universit√© Catholique de Louvain, Avenue Hippocrate 55, B-1200 Brussels, Belgium.


The control of glucagon secretion by pancreatic alpha-cells is poorly understood, largely because of the difficulty to recognize living alpha-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy alpha-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca(2+)](c) responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study alpha-cells.

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