Breast Cancer Res. 2007;9(4):305.

Amping up estrogen receptors in breast cancer.

Source

Department of Oncology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

This article highlights a recent study by Holst et al. in Nature Genetics that finds estrogen receptor-alpha (ER-alpha) amplification in early benign lesions and more advanced invasive carcinomas of the breast, and discusses the potential implications to our present understanding of the role of ER-alpha in breast tumorigenesis.

PMID:: 17705882; [PubMed - indexed for MEDLINE]
PMCID:: PMC2206721

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Estrogen Receptor alpha

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Breast Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects. [Ann N Y Acad Sci. 2009]
Review Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects.
Santen R, Cavalieri E, Rogan E, Russo J, Guttenplan J, Ingle J, Yue W. Ann N Y Acad Sci. 2009 Feb; 1155:132-40.
Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. [Cancer Res. 2009]
Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer.
Peters AA, Buchanan G, Ricciardelli C, Bianco-Miotto T, Centenera MM, Harris JM, Jindal S, Segara D, Jia L, Moore NL, et al. Cancer Res. 2009 Aug 1; 69(15):6131-40. Epub 2009 Jul 28.
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. [Breast Cancer Res. 2008]
Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.
Neubauer H, Clare SE, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Vogel U, Sotlar K, Wallwiener D, Kurek R, et al. Breast Cancer Res. 2008; 10(5):R85. Epub 2008 Oct 15.
Review Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target. [J Steroid Biochem Mol Biol. 2008]
Review Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target.
Skliris GP, Leygue E, Watson PH, Murphy LC. J Steroid Biochem Mol Biol. 2008 Mar; 109(1-2):1-10. Epub 2007 Dec 8.
Expression of estrogen receptor alpha and beta in breast cancers of pre- and post-menopausal women. [Pathol Oncol Res. 2008]
Expression of estrogen receptor alpha and beta in breast cancers of pre- and post-menopausal women.
Murillo-Ortiz B, Pérez-Luque E, Malacara JM, Daza-Benítez L, Hernández-González M, Benítez-Bribiesca L. Pathol Oncol Res. 2008 Dec; 14(4):435-42. Epub 2008 Aug 28.

See reviews... See all...

Cited by 4 PubMed Central articles

Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways. [PLoS One. 2012]
Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.
Lim EJ, Hong DY, Park JH, Joung YH, Darvin P, Kim SY, Na YM, Hwang TS, Ye SK, Moon ES, et al. PLoS One. 2012; 7(4):e33361. Epub 2012 Apr 2.
Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm. [BMC Cell Biol. 2009]
Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm.
Meng Y, Wu Z, Yin X, Zhao Y, Chen M, Si Y, Yang J, Fu X, Han W. BMC Cell Biol. 2009 Dec 26; 10:96. Epub 2009 Dec 26.
Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer. [Mol Cancer. 2009]
Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer.
Ren Y, Wu L, Frost AR, Grizzle W, Cao X, Wan M. Mol Cancer. 2009 Nov 27; 8:111. Epub 2009 Nov 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Amping up estrogen receptors in breast cancer.
Amping up estrogen receptors in breast cancer.
Breast Cancer Res. 2007 ;9(4):305.

PubMed
Extensive parallelism in protein evolution.
Extensive parallelism in protein evolution.
Biol Direct. 2007 Aug 16 ;2:20.

PubMed
[Arrhythmias--classification and definition].
[Arrhythmias--classification and definition].
Nihon Rinsho. 1991 Nov ;49(11):2479-86.

PubMed
Genomic mapping of Suppressor of Hairy-wing binding sites in Drosophila.
Genomic mapping of Suppressor of Hairy-wing binding sites in Drosophila.
Genome Biol. 2007 ;8(8):R167.

PubMed
The AMP-activated protein kinase: more than an energy sensor.
The AMP-activated protein kinase: more than an energy sensor.
Essays Biochem. 2007 ;43:121-37.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: