Wien Med Wochenschr. 2007;157(13-14):367-70.

Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid.

Source

Max Zeller Söhne AG, Romanshorn, Switzerland. Axel.Brattstroem@ZellerAG.ch

Abstract

Valerian and hops are traditionally used as sleep-inducing aids. Alertness reduces gradually with the prolongation of wakefulness through the release of endogenous adenosine in the frontal basal cortex. Valerian has an adenosine-like action and supports the readiness to fall asleep. The control of the sleep-wake rhythm induces sleep when the time-related interaction is operating properly. The control is closely related to endogenous melatonin secretion. Hops act in a similar way to melatonin. Therefore, the efficacy of a valerian and hops combination in sleep disorder can scientifically be explained.

PMID:: 17704989; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. [Phytother Res. 2007]
A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder.
Koetter U, Schrader E, Käufeler R, Brattström A. Phytother Res. 2007 Sep; 21(9):847-51.
In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. [Phytomedicine. 2004]
In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors.
Abourashed EA, Koetter U, Brattström A. Phytomedicine. 2004 Nov; 11(7-8):633-8.
Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms. [Eur J Med Res. 2008]
Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms.
Dimpfel W, Suter A. Eur J Med Res. 2008 May 26; 13(5):200-4.
Review Treating primary insomnia - the efficacy of valerian and hops. [Aust Fam Physician. 2010]
Review Treating primary insomnia - the efficacy of valerian and hops.
Salter S, Brownie S. Aust Fam Physician. 2010 Jun; 39(6):433-7.
Review Valerian use for sleep disturbances related to rheumatoid arthritis. [Holist Nurs Pract. 2004]
Review Valerian use for sleep disturbances related to rheumatoid arthritis.
Taibi DM, Bourguignon C, Taylor AG. Holist Nurs Pract. 2004 May-Jun; 18(3):120-6.

See reviews... See all...

Cited by 1 PubMed Central article

A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia. [Sleep Med. 2009]
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
Taibi DM, Vitiello MV, Barsness S, Elmer GW, Anderson GD, Landis CA. Sleep Med. 2009 Mar; 10(3):319-28. Epub 2008 May 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Scientific evidence for a fixed extract combination (Ze 91019) from valerian and...
Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid.
Wien Med Wochenschr. 2007 ;157(13-14):367-70.

PubMed
Hand-assisted versus laparoscopic-assisted colorectal surgery: Practice patterns...
Hand-assisted versus laparoscopic-assisted colorectal surgery: Practice patterns and clinical outcomes in a minimally-invasive colorectal practice.
Surg Endosc. 2008 Mar ;22(3):739-43.

PubMed
Laparoscopic cholecystectomy for severe acute cholecystitis. A meta-analysis of ...
Laparoscopic cholecystectomy for severe acute cholecystitis. A meta-analysis of results.
Surg Endosc. 2008 Jan ;22(1):8-15. Epub 2007 Aug 18 .

PubMed
The role of DJ-1 in the pathogenesis of Parkinson's disease.
The role of DJ-1 in the pathogenesis of Parkinson's disease.
Neurosci Bull. 2006 Jul;22(4):232-234.

PubMed
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synt...
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.
Nat Struct Mol Biol. 2007 Sep ;14(9):875-7. Epub 2007 Aug 19 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: