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Curr Opin Plant Biol. 2007 Oct;10(5):534-42. Epub 2007 Aug 20.

Mapping the genome landscape using tiling array technology.

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  • 1The Salk Institute for Biological Studies, Plant Molecular and Cellular, Laboratory 10010 North Torrey Pines Road La Jolla, CA 92037, USA.

Abstract

With the availability of complete genome sequences for a growing number of organisms, high-throughput methods for gene annotation and analysis of genome dynamics are needed. The application of whole-genome tiling microarrays for studies of global gene expression is providing a more unbiased view of the transcriptional activity within genomes. For example, this approach has led to the identification and isolation of many novel non-protein-coding RNAs (ncRNAs), which have been suggested to comprise a major component of the transcriptome that have novel functions involved in epigenetic regulation of the genome. Additionally, tiling arrays have been recently applied to the study of histone modifications and methylation of cytosine bases (DNA methylation). Surprisingly, recent studies combining the analysis of gene expression (transcriptome) and DNA methylation (methylome) using whole-genome tiling arrays revealed that DNA methylation regulates the expression levels of many ncRNAs. Further capture and integration of additional types of genome-wide data sets will help to illuminate additional hidden features of the dynamic genomic landscape that are regulated by both genetic and epigenetic pathways in plants.

PMID:
17703988
[PubMed - indexed for MEDLINE]
PMCID:
PMC2665186
Free PMC Article

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