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Semin Cell Dev Biol. 2008 Feb;19(1):24-33. Epub 2007 Jul 10.

Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.

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  • 1Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.

Abstract

Enzymes in the matrix metalloproteinase (MMP) family have been linked to key events in developmental biology for almost 50 years. Biochemical, cellular and in vivo analyses have established that pericellular proteolysis contributes to numerous aspects of ontogeny including ovulation, fertilization, implantation, cellular migration, tissue remodeling and repair. Surface anchoring of proteinase activity provides spatial restrictions on substrate targeting. This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP.

PMID:
17702616
[PubMed - indexed for MEDLINE]
PMCID:
PMC2685078
Free PMC Article
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