Send to:

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2008 Feb;19(1):24-33. Epub 2007 Jul 10.

Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.

Author information

  • 1Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.


Enzymes in the matrix metalloproteinase (MMP) family have been linked to key events in developmental biology for almost 50 years. Biochemical, cellular and in vivo analyses have established that pericellular proteolysis contributes to numerous aspects of ontogeny including ovulation, fertilization, implantation, cellular migration, tissue remodeling and repair. Surface anchoring of proteinase activity provides spatial restrictions on substrate targeting. This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk