J Clin Psychopharmacol. 1991 Dec;11(6):344-50.

A controlled study of alprazolam and propranolol in panic-disordered and agoraphobic outpatients.

Ravaris CL, Friedman MJ, Hauri PJ, McHugo GJ.

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Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire.

Abstract

We studied the efficacy of propranolol (Inderal) compared to alprazolam (Xanax) in 29 patients with a diagnosis of agoraphobia with panic disorder or panic disorder with or without limited phobic avoidance in a 6-week double-blind controlled experiment. Alprazolam is effective in those syndromes, whereas to date only negative or ambiguous results had been reported for propranolol. Fourteen patients received a mean daily dose of 5.0 +/- 2.3 mg of alprazolam and 15 patients received 182.0 +/- 60.5 mg mean daily dose of propranolol. We found both drugs to be effective to suppress panic attacks and reduce avoidance behavior. The only significant between-drug difference was a more rapid onset of alprazolam's panicolytic effect. Propranolol merits further study. We suggest patients worthy of a clinical trial.

PMID:: 1770152; [PubMed - indexed for MEDLINE]

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