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Nano Lett. 2007 Sep;7(9):2819-23. Epub 2007 Aug 16.

One- and two-photon excited optical ph probing for cells using surface-enhanced Raman and hyper-Raman nanosensors.

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  • 1Harvard University Medical School, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA. jkneipp@janina-kneipp.de


We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid (pMBA) on gold nanoaggregates. Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). In addition to the advantages of two-photon excitation, the SEHRS sensor enables measurements over a wide pH range without the use of multiple probes.

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