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Anticancer Res. 2007 Jul-Aug;27(4B):2115-20.

MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma.

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  • 1National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland. Lorraine.ODriscoll@dcu.ie

Abstract

BACKGROUND:

Pancreatic cancer is one of the most challenging solid organ malignancies. This is due to its aggressiveness, frequent late presentation as advanced disease and chemoresistance. A better understanding of the molecular basis of its drug resistance is needed.

MATERIALS AND METHODS:

In this study, the first of its kind, the expression of both MDR1 P-gp and MRP-1 protein in pancreatic tumour specimens was examined by immunohistochemistry. Expression of these drug efflux pumps was examined using semi-quantitative immunohistochemistry according to the percentage of cells within the tumour, demonstrating another staining intencity.

RESULTS:

Overall, 93.3% of pancreatic carcinomas expressed MDR1 P-gp, approximately 31% co-expressed MRP-1 with MDR1 P-gp, while 6.7% expressed neither of these proteins.

CONCLUSION:

Our results show that drug efflux pumps, in particular that of MDR1 P-gp, are frequently expressed in pancreatic cancer. While a causative role for these efflux pumps in pancreatic cancer chemoresistance cannot necessarily be concluded, the information presented here should be considered when selecting chemotherapy/drug efflux pump inhibitors for future therapies.

PMID:
17695494
[PubMed - indexed for MEDLINE]
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