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Anticancer Res. 2007 Jul-Aug;27(4C):2903-10.

Course of mitogen-stimulated T lymphocytes in cancer patients treated with Viscum album extracts.

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  • 1Krebsforschung Herdecke, Department of Applied Immunology, Bochum, Germany. arndt.buessing@uni-wh.de

Abstract

BACKGROUND:

In a prospective observational study, the impact of two different dose regimes of a commercially available fermented Viscum album L. extract (VA-E, Iscador) on the function of T lymphocytes from cancer patients was investigated.

PATIENTS AND METHODS:

A total of 71 cancer patients were enrolled. These patients attended two different sections of a tumor outpatient clinic which are used to apply different VA-E escalation schemes. Our hypothesis was that a rapid dose escalation of subcutaneously applied VA-E may induce strong local reactions at the injection side (>3 cm diameter) and may have an effect on the functional competence of T lymphocytes (mitogen-activated interleukin-2 receptor alpha chain), which was recorded over an observation period of six month.

RESULTS:

Within this observation period, a decline of stimulated T cell function was observed, particularly in patients with colorectal or prostate cancer; this decline was not seen in patients with breast cancer (who received lower mean concentrations per month) nor in patients with dose adaptation in response to too strong local reactions.

CONCLUSION:

With respect to T-cell function, our results indicate that in patients without local reactions, a long lasting mistletoe extract application should be withheld periodically to allow T-cell reactivity to recover.

PMID:
17695469
[PubMed - indexed for MEDLINE]
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