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Bioprocess Biosyst Eng. 2008 Feb;31(2):63-7. Epub 2007 Aug 11.

Enhancing yield of S-adenosylmethionine in Pichia pastoris by controlling NH4+ concentration.

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  • 1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.


Yield of S-adenosylmethionine was improved significantly in recombinant Pichia pastoris by controlling NH(4)(+) concentration. The highest production rate was 0.248 g/L h when NH(4)(+) concentration was 450 mmol/L and no repression of cell growth was observed. Within very short induction time (47 h), 11.63 g/L SAM was obtained in a 3.7 L bioreactor.

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