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Nat Neurosci. 2007 Sep;10(9):1134-6. Epub 2007 Aug 12.

Experience-dependent recovery of vision following chronic deprivation amblyopia.

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  • 1Department of Biology, University of Maryland, College Park, Maryland 20742, USA.

Abstract

The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly thereafter. However, here we demonstrate that complete visual deprivation through dark exposure restores rapid ocular dominance plasticity in adult rats. In addition, the loss of visual acuity resulting from chronic monocular deprivation is reversed if dark exposure precedes removal of the occlusion in adulthood, suggesting a potential use for dark exposure in the treatment of adult amblyopia.

PMID:
17694050
[PubMed - indexed for MEDLINE]
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