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J Occup Environ Med. 2007 Aug;49(8):872-9.

Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate.

Author information

  • 1Yale University School of Medicine, New Haven, Connecticut, USA. carine.sakr@yale.edu

Erratum in

  • J Occup Environ Med. 2007 Nov;49(11):1294.

Abstract

OBJECTIVE:

To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.

METHODS:

We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.

RESULTS:

One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.

CONCLUSIONS:

These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

PMID:
17693785
[PubMed - indexed for MEDLINE]
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