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J Med Chem. 2007 Sep 6;50(18):4539-42. Epub 2007 Aug 11.

Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging.

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  • 1Laboratorio de Síntesis OrgAnica e Imagen Molecular por Resonancia Magnética, Instituto Universitario de Investigación, UNED, Paseo Senda del Rey 9, 28040 Madrid, Spain.


We describe the synthesis of 1,omega-di-1H-imidazoles 2 and 3, derived from l-threitol and d-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for 1H spectroscopic imaging by magnetic resonance methods.

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