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Science. 2007 Aug 10;317(5839):813-5.

Adaptive mutations in bacteria: high rate and small effects.

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  • 1Instituto Gulbenkian de Ciência, Rua da Quinta Grande, number 6, 2780-156 Oeiras, Portugal.

Abstract

Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10(-5) per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.

PMID:
17690297
[PubMed - indexed for MEDLINE]
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