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Gene. 2007 Oct 15;401(1-2):1-3. Epub 2007 Jul 18.

Balanced production of ribosomal proteins.

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  • 1Fox Chase Cancer Center, Philadelphia, PA 19111, USA.


Eukaryotic ribosomes contain one molecule each of 79 different proteins. The genes encoding these proteins are usually at widely scattered loci and have distinctive promoters with certain common features. This minireview discusses the means by which cells manage to balance the production of ribosomal proteins so as to end up with equimolar quantities in the ribosome. Regulation at all levels of gene expression, from transcription to protein turnover, is considered.

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