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Am J Obstet Gynecol. 2007 Aug;197(2):195.e1-7; discussion 195.e7-8.

Cervical adenocarcinoma in situ: the predictive value of conization margin status.

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  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia School of Medicine, Charlottesville 22908-0712, USA. jly2y@virginia.edu

Abstract

OBJECTIVE:

We evaluated the impact of conization margin status on outcomes of patients diagnosed with cervical adenocarcinoma in situ.

STUDY DESIGN:

A retrospective chart review identified patients at a University hospital from 1988-2006 with adenocarcinoma in situ (AIS) on conization.

RESULTS:

Seventy-four patients were included. Median follow-up was 26 months. Twenty-two of 74 patients (30%) had positive margins, 46 patients (62%) had negative margins, and 6 patients had indeterminate margins. Of patients with positive margins, 55% (12/22) were diagnosed with residual or recurrent disease, including 3 patients diagnosed with adenocarcinoma on hysterectomy. Thirteen percent of patients with negative conization margins (6/46) were diagnosed with residual or recurrent disease, including 2 patients diagnosed with adenocarcinoma during follow-up. Cold knife conization resulted in a significantly higher number of negative margins compared to other conization procedures (P = .013).

CONCLUSIONS:

Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.

PMID:
17689647
[PubMed - indexed for MEDLINE]
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