Successful pregnancy with the use of nitric oxide donors and heparin after recurrent severe preeclampsia in a woman with scleroderma

Bruno Carbonne; Guillaume Macé; Evelyne Cynober; Jacques Milliez; Jean Cabane

doi:10.1016/j.ajog.2007.04.025

Successful pregnancy with the use of nitric oxide donors and heparin after recurrent severe preeclampsia in a woman with scleroderma

Am J Obstet Gynecol. 2007 Aug;197(2):e6-7. doi: 10.1016/j.ajog.2007.04.025.

Authors

Bruno Carbonne¹, Guillaume Macé, Evelyne Cynober, Jacques Milliez, Jean Cabane

Affiliation

¹ Department of Obstetrics and Gynecology, Hôpital Saint-Antoine, Paris, France. bruno.carbonne@sat.aphp.fr

PMID: 17689619
DOI: 10.1016/j.ajog.2007.04.025

Abstract

We report the case of a woman with scleroderma who had severe, early-onset preeclampsia on 2 consecutive pregnancies. With a treatment that included aspirin, heparin, and a nitric oxide donor, her third pregnancy ended with a healthy neonate at term. Nitric oxide donors and heparin may play a preventive role on placental dysfunction in scleroderma.

Publication types

Case Reports

MeSH terms

Adult
Aspirin / therapeutic use
Female
Heparin, Low-Molecular-Weight / administration & dosage*
Humans
Nitric Oxide Donors / administration & dosage*
Pre-Eclampsia / prevention & control*
Pregnancy
Pregnancy Complications*
Recurrence
Scleroderma, Systemic / complications*

Substances

Heparin, Low-Molecular-Weight
Nitric Oxide Donors
Aspirin